Figure 1: Differential Effects of BLOC-1 Complex Null Mutations in the Number of Parvalbumin-Positive Neurons. Hippocampal sections from wild type, Bloc1s8sdy/sdy, Bloc1s5mu/mu, and Bloc1s6pa/pa postnatal day 50 adults were stained with antibodies against parvalbumin and imaged by confocal microscopy. (A) Depicts sections of the dentate gyrus and CA1 (upper panels) and the CA3 area (bottom panels) for four genotypes. (B) Depicts quantitation of the number of parvalbumin positive cells per section in each one of the genotypes. Cell counts were performed blind to the genotype of the animal. Wild type (n = 9), Bloc1s8sdy/sdy (n = 7), Bloc1s5mu/mu (n = 7), and Bloc1s6pa/pa (n = 6) hippocampi analyzed. One Way ANOVA followed by Dunnett’s Multiple Comparison.
Figure 1 from a recent publication with students at Agnes Scott:
Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus. Front Genet. 2017 Mar 10;8:28. doi: 10.3389/fgene.2017.00028. eCollection 2017.